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Preventive effect of polynucleotide on post‐thyroidectomy scars: A randomized, double‐blinded, controlled trial
Author(s) -
Kim Ji Hee,
Jeong Jong Ju,
Lee Young In,
Lee Won Jai,
Lee Chorok,
Chung Woong Youn,
Nam KeeHyun,
Lee Ju Hee
Publication year - 2018
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22812
Subject(s) - medicine , scars , thyroidectomy , erythema , hyperpigmentation , surgery , hypertrophic scar , saline , ablative case , adverse effect , wound healing , randomized controlled trial , thyroid , urology , dermatology , radiation therapy
Background and Objective Polynucleotide (PN) provides a structural scaffold to induce anti‐inflammatory and enhanced wound healing properties, and this study aimed to assess the efficacy of PN administration in the prevention of post‐operative scars after conventional open total thyroidectomy. Study Design Materials and Methods Forty‐two patients with thyroid carcinoma who underwent total thyroidectomy were randomly assigned to the study (PN administration) or control (normal saline) group. All patients underwent a single session of combined ablative and non‐ablative fractional laser. The Vancouver Scar Scale (VSS), global photographic assessment, and objective scar were assessed using three‐dimensional (3D) camera at baseline and at 2, 4, 8, and 16 weeks after surgery. Results Patients who underwent PN injection demonstrated better surgical scar quality outcome. Participants in the PN administration group had lower VSS scores than the control group (2.09 ± 0.47 vs. 4.01 ± 0.55, respectively) and lower scar height (0.23 ± 0.03 vs. 0.29 ± 0.03, respectively), as measured using 3D imaging. Furthermore, in the PN injected group, the degree of erythema, and pigmentation of the scar were less prominent. No patient developed hypertrophic scar or keloids on the surgical site. No other adverse events, including post‐inflammatory hyperpigmentation, scarring, or infection, were observed. Conclusion Adjuvant administration of PN along with conventional fractional laser treatment led to more favorable effect in wound healing and post‐operative scar prevention after thyroidectomy. Lasers Surg. Med. 50:755–762, 2018. © 2018 Wiley Periodicals, Inc.