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Optical coherence tomography angiography of macular telangiectasia type 1: Comparison with mild diabetic macular edema
Author(s) -
Mao Lei,
Weng Sisi,
Gong Yuanyuan,
Yu Suqin
Publication year - 2017
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22645
Subject(s) - macular telangiectasia , medicine , ophthalmology , optical coherence tomography , fluorescein angiography , optical coherence tomography angiography , telangiectasia , retinal , foveal avascular zone , diabetic macular edema , angiography , macular edema , edema , diabetic retinopathy , pathology , radiology , surgery , diabetes mellitus , endocrinology
Objective The present study aimed to investigate the characteristics of macular telangiectasia type 1 (Mac tel type 1) using spectral‐domain optical coherence tomography angiography (OCTA) and compare them with the characteristics of mild diabetic macular edema (DME), to provide a new objective method for quick clinical diagnosis and treatment. Methods A retrospective comparative analysis of 9 Mac tel type 1, 15 DME, and 15 normal eyes was performed using fluorescein angiography, spectral‐domain optical coherence tomography, and OCTA. The morphological changes, retinal vessel density, and nonperfused areas were evaluated using split‐spectrum amplitude‐decorrelation angiography algorithm. Results OCTA revealed obvious saccular capillary telangiectasia and loss of parafoveal vascular density of Mac tel type 1. However, a number of line segment hyperreflective signals around the macula and more distinct nonperfusion in DME were observed. The quantitative foveal avascular zone mean area in Mac tel type 1 was larger than that in the normal eyes (0.40 ± 0.06 mm 2 vs. 0.88 ± 0.19 mm 2 , P < 0.001). However, the area in DME (1.52 ± 0.38 mm 2 ) was larger than that in Mac tel type 1 ( P < 0.001), and the foveal zone area in DME (1.127 ± 0.05 mm 2 ) was also lager than it in Mac tel ( P < 0.05). The vascular density of the superficial layer reduced in both Mac tel type 1 and DME (compared with normal eyes). The difference between Mac tel type 1 (49.56 ± 5.23)% and DME(44.58 ± 3.82)% was significant in the superficial capillary layer ( P < 0.01). The vascular density of the retinal deep layer also reduced in both Mac tel type 1 and DME (compared with normal eyes). The difference between Mac tel type 1 (53.78 ± 7.36)% and DME (53.64 ± 4.96)% was no significant in this layer ( P > 0.05). Conclusion Morphological differences between Mac tel 1 and DME can be observed on OCTA. Superficial vascular density and non‐perfusion area may serve as a quantitative method to identify them. Lasers Surg. Med. 49:225–232, 2017. © 2017 Wiley Periodicals, Inc.