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Sensitivity and specificity of multispectral imaging in detecting central serous chorioretinopathy
Author(s) -
Zhu Xuemei,
Cheng Yong,
Pan Xue,
Jin Enzhong,
Li Shanshan,
Zhao Mingwei,
Li Xiaoxin
Publication year - 2017
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22619
Subject(s) - medicine , serous fluid , retinal pigment epithelium , fluorescein angiography , ophthalmology , retinal detachment , indocyanine green , indocyanine green angiography , retinal , optical coherence tomography , radiology , pathology
Background and Objective Central serous chorioretinopathy (CSCR) is a common and idiopathic retinal disorder that affects young to middle aged adults. The aim of this study was to describe the characteristics of eyes with CSCR using a light‐emitting diode (LED)‐based multispectral imaging (MSI) system and to evaluate the diagnostic reliability of MSI compared to fluorescein angiography (FA) in detecting CSCR. Materials and Methods A total of 56 eyes among 52 patients with 1 or more retinal pigment epithelium (RPE) abnormality were retrospectively enrolled in the study. The patients underwent complete examination, including optical coherence tomography, FA, indocyanine‐green angiography, and MSI. MSI images were retrospectively reviewed by experienced masked graders. Diagnoses that were made based on MSI alone were compared with those that were made using FA. Sensitivity and specificity were calculated, and the morphological features on MSI were summarized. Results Among 56 eyes in 52 patients, MSI detected 22 of 26 true‐positive CSCR cases but missed 4 FA‐confirmed lesions. Further, it correctly excluded 30 of 30 non‐CSCR lesions. The sensitivity and specificity of MSI were 84.6 and 100%, respectively, for identifying CSCR. Using MSI, RPE leakage was observed in 25 (96.2%) of 26 eyes with CSCR, which was comparable to the performance of FA. Dome‐shaped areas of signal, which corresponded to fluid accumulation associated with neurosensory retinal detachment or RPE detachment were observed in 23 (88.5%) of 26 eyes. Conclusions As a non‐invasive technique, MSI permitted the visualization of RPE leakage and neurosensory detachment and allowed good detection of CSCR in this selected clinical population. Lasers Surg. Med. 49:498–505, 2017. © 2016 Wiley Periodicals, Inc.