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Effect of Nd:YAG laser‐assisted non‐surgical periodontal therapy on clinical periodontal and serum biomarkers in patients with and without coronary artery disease: A short‐term pilot study
Author(s) -
Javed Fawad,
Kellesarian Sergio V.,
AlKheraif Abdulaziz A.,
Ranna Vinisha,
Qadri Talat,
Yunker Michael,
Malmstrom Hans,
Romanos Georgios E.
Publication year - 2016
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22483
Subject(s) - medicine , coronary artery disease , bleeding on probing , gastroenterology , periodontal disease , matrix metalloproteinase , dentistry
Background/Objective We hypothesized that nonsurgical‐periodontal‐therapy (NSPT) with adjunct Nd:YAG laser therapy is more effective in reducing periodontal inflammatory parameters (plaque index [PI], bleeding‐on‐probing [BOP], and probing‐pocket‐depth [PPD]) and serum interleukin‐1beta (IL‐1β) and matrix metalloproteinase‐9 (MMP‐9) levels in patients with and without coronary artery disease (CAD) than NSPT alone. The aim of this short‐term pilot study was to assess the effect of NSPT + Nd:YAG laser therapy on periodontal parameters and serum IL‐1β and MMP‐9 levels in patients with and without CAD. Study Design A prospective randomized clinical study was conducted on 87 patients who were divided into two groups: Group‐1: 44 patients with CAD and periodontal disease (PD) and Group‐2: 43 patients with PD alone. Treatment‐wise, these individuals were randomly divided into two subgroups: (i) NSPT alone and (ii) NSPT + Nd:YAG laser therapy. Demographic information was collected using a self‐completed questionnaire. Periodontal parameters (PI, BOP, and PPD) and serum IL‐1β and MMP‐9 levels were measured at baseline and after 3 months of treatment. P ‐values <0.05 were considered statistically significant. Results At 3 months follow‐up, PI ( P < 0.01), BOP ( P < 0.01), PPD ≥ 4 mm ( P < 0.01), and serum IL‐1β ( P < 0.01) and MMP‐9 ( P < 0.01) levels were significantly higher in patients treated with NSPT alone than those treated with NSPT + Nd:YAG laser therapy. Among patients that underwent NSPT + laser therapy in both groups, periodontal parameters and serum IL‐1β, and MMP‐9 levels were comparable at 3‐months follow‐up. Conclusion NSPT + Nd:YAG laser therapy may be more effective in reducing periodontal inflammation and serum IL‐1β and MMP‐9 levels in patients with and without CAD than NSPT alone. Lasers Surg. Med. 48:929–935, 2016. © 2016 Wiley Periodicals, Inc.