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Preliminary study of optical coherence tomography imaging to identify microscopic extrathyroidal extension in patients with papillary thyroid carcinoma
Author(s) -
Lee Hyoung Shin,
Shin Sung Won,
Bae Jung Kweon,
Jung Woong Gyu,
Kim Sung Won,
Oak Chulho,
Chun Bong Kwon,
Ahn YehChan,
Lee ByungJoo,
Lee Kang Dae
Publication year - 2016
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22466
Subject(s) - optical coherence tomography , medicine , thyroidectomy , histopathology , thyroid carcinoma , ex vivo , thyroid , nuclear medicine , radiology , carcinoma , pathology , in vivo , microbiology and biotechnology , biology
Background and Objectives We evaluated the feasibility of using optical coherence tomography (OCT), to identify microscopic extrathyroidal extension (mETE) in ex vivo thyroidectomy specimens of patients who underwent thyroidectomy for the treatment of papillary thyroid carcinoma (PTC). Methods A total of 170 ex vivo OCT images of the tumor, were acquired just after completion of thyroidectomy in 17 patients. The OCT images of each patient were separately evaluated by two blinded investigators, and the outcomes were compared with the histopathology reports. Results The sensitivity and specificity of mETE identification from the OCT images were 81.4% and 86.0%, respectively, for the first investigator, and 82.9% and 87.0%, respectively, for the second investigator. Substantial agreement between the investigators was verified by Cohen's κ (Cohen's κ = 0.772). Conclusion In this preliminary study of a limited series of ex vivo thyroidectomy specimens, we verified the feasibility of OCT as a method of identifying mETE in patients with PTC. Lasers Surg. Med. 48:371–376, 2016. © 2015 Wiley Periodicals, Inc.