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Short‐term microbiological effects of photodynamic therapy in non‐surgical periodontal treatment of residual pockets: A split‐mouth RCT
Author(s) -
Corrêa Mônica Grazieli,
Oliveira Deborah Haydee,
Saraceni Cintia Helena Coury,
Ribeiro Fernanda Vieira,
Pimentel Suzana Peres,
Cirano Fabiano Ribeiro,
Casarin Renato Corrêa Viana
Publication year - 2016
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22449
Subject(s) - scaling and root planing , photodynamic therapy , aggregatibacter actinomycetemcomitans , medicine , dentistry , bleeding on probing , gingival and periodontal pocket , randomized controlled trial , chronic periodontitis , periodontitis , clinical attachment loss , clinical trial , porphyromonas gingivalis , chemistry , organic chemistry
Background and Objective Photodynamic therapy (PDT) has been used as a therapeutic alternative to treat periodontitis, especially in challenging sites that require additional periodontal therapy such as residual pockets. The aim of this split‐mouth randomized trial was to evaluate the microbiological and clinical effects of PDT on non‐surgical treatment of unresponsive pockets. Study Design/Materials and Methods A split‐mouth, randomized controlled clinical trial was conducted in 15 patients presenting at least two residual pockets (probing pocket depth [PPD] ≥5 mm with bleeding on probing [BoP]) in single‐rooted teeth in supportive periodontal therapy. The selected sites randomly received: (1) SRP + PDT: scaling and root planing combined with photodynamic therapy (methylene blue as a photosensitizer), or (2) SRP: scaling and root planing alone. The concentrations of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans were evaluated using a Real‐time PCR technique at baseline and 3, 7, 14, and 90 days. Clinical parameters were assessed at baseline and 3 months post‐therapies. Results Both treatments promoted clinical improvements, with additional benefits to the SRP + PDT group in PPD reduction and clinical attachment level gain ( P < 0.05) after 3 months. Only the SRP + PDT group exhibited a statistically significant reduction in the levels of A. actinomycetemcomitans on the 3rd and 7th days after therapy ( P < 0.05), and a lower concentration of this pathogen was detected at 7 days in the SRP + PDT group when compared to the other therapy ( P < 0.05). Conclusion The combined therapeutic approach SRP + PDT may reduce A. actinomycetemcomitans levels for a short‐term period, associated with additional improvement in clinical parameters in treating residual pockets. Lasers Surg. Med. 48:944–950, 2016. © 2015 Wiley Periodicals, Inc.