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The hyper‐fluorescent transitional bands in ultra‐late phase of indocyanine green angiography in chronic central serous chorioretinopathy
Author(s) -
Hua Rui,
Yao Kai,
Xia Fan,
Li Jun,
Guo Lei,
Yang Guoxing,
Tao Jun
Publication year - 2016
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22434
Subject(s) - retinal pigment epithelium , indocyanine green , medicine , serous fluid , ophthalmology , retinal , atrophy , retina , fluorescein angiography , pathology , optics , physics
Background and Objectives Chronic central serous chorioretinopathy (CSCR) is regarded as a type of severe diffuse retinal pigment epitheliopathy. There is an atrophic tract at level of retinal pigment epithelium (RPE) due to hyper‐permeability of choroidal vessels, along with photoreceptor (PR) atrophy. Indocyanine green angiography (ICGA) is considered a gold standard for diagnosis. The purpose of this work is to investigate the hyper‐fluorescent transitional bands (HFTB) between hypo‐fluorescent and normal regions of the retina in the ultra‐late phase of ICGA in CSCR. Methods 26 chronic CSCR eyes and 12 relative normal eyes received spectral domain optical coherence tomography (SD‐OCT), and ICGA at the 24th hour after indocyanine green (ICG) intravenous injection. Results In the ultra‐late phase, images showed homogenous fluorescence in all normal eyes. On the contrary, geographical hypofluorescent lesions with atrophy of RPE was noted in 26 chronic CSCR eyes. Moreover, HFTB with intact RPE and disrupted PR was detected in 20 out of 26 chronic CSCR eyes (76.9%). Conclusions The HFTB may indicate the early damage in chronic CSCR. Ultra‐late ICGA can monitor not only metabolic status by endogenous melanin, but also membrane function in RPE by exogenous ICG molecule. Lasers Surg. Med. 48:260–263, 2016. © 2015 Wiley Periodicals, Inc.