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A light‐emitting diode (LED)‐based multispectral imaging system in evaluating retinal vein occlusion
Author(s) -
Xu Yupeng,
Liu Xiaoxiao,
Cheng Lu,
Su Li,
Xu Xun
Publication year - 2015
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22392
Subject(s) - medicine , retinal , receiver operating characteristic , retinal vein , ophthalmology , macular edema , occlusion , central retinal vein occlusion , fundus (uterus) , cotton wool spots , epiretinal membrane , branch retinal vein occlusion , fundus photography , fluorescein angiography , retinopathy , visual acuity , surgery , vitrectomy , diabetes mellitus , endocrinology
Background and Objective Retinal vein occlusion (RVO), the second most common retinal vascular disorder worldwide, is considered to be a critical cause of visual loss. The aim of this study was to describe the characteristics of eyes with RVO using a light‐emitting diode (LED)‐based multispectral imaging (MSI) system and to compare its performance in terms of reliability and diagnostic power with those of fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and fundus photography (FP). Materials and Methods Fifty‐six eyes of 28 patients with RVO disease were evaluated by MSI, FP, FFA, and spectral domain OCT. All images were analyzed by an experienced reading center grader. Nonperfusion area, occlusion area, and intraretinal edema from occlusions and FP abnormalities (presence of cotton‐wool spots, epiretinal membrane, hard exudates, and retinal hemorrhage) were documented. The diagnostic power of MSI was evaluated by the area under receiver operating characteristic (ROC) curve (AUC). Results Of the 56 eyes, 15 had branch RVO (BRVO), 13 had central RVO (CRVO), and 28 were normal. The ROC curve analysis showed that MSI was a better discriminator of RVO than FP (AUC = 0.911 vs. 0.768, P = 0.0318). The sensitivity (and 95% confidence intervals) of MSI for nonperfusion area was 42.3% (18.8–70.4), 80.0% (51.4–94.7) for retinal hemorrhage, 90.0% (54.1–99.5) for cotton‐wool spots, 90.9% (57.1–99.5) for hard exudates, and 21.1% (7.0–46.1) for intraretinal edema. MSI was capable of finding abnormalities such as nonperfusion area, retinal hemorrhage, cotton‐wool spots, hard exudates, and epiretinal membrane. MSI oxy–deoxy maps showed low oxygen levels in the affected vein, especially in CRVOs, and could be used in detecting the nonperfusion area. Conclusion MSI reveals highly defined vascular abnormalities in shortwave images and oxy–deoxy maps, which is compatible with FP, FFA, and OCT findings and indicates, preliminarily, the advantages of the noninvasiveness, simplicity, and effectiveness of MSI in evaluating RVO diseases. Lasers Surg. Med. 47:549–558, 2015. © 2015 Wiley Periodicals, Inc.