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The effect of low‐level laser therapy (LLLT) applied prior to muscle injury
Author(s) -
Ribeiro Beatriz Guimarães,
Alves Agnelo Neves,
Santos Lucas Andreo Dias dos,
Fernandes Kristianne Porta Santos,
Cantero Tatiane Matarazzo,
Gomes Mariana Teixeira,
França Cristiane Miranda,
de Fátima Teixeira da Silva Daniela,
Bussadori Sandra Kalil,
MesquitaFerrari Raquel Agnelli
Publication year - 2015
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22381
Subject(s) - low level laser therapy , medicine , matrix metalloproteinase , muscle tissue , wound healing , laser therapy , surgery , laser , physics , optics
Aim To evaluate the effect of LLLT (780 nm; 10 J/cm 2 , 40 mW, 3.2 J) prior to injury on the morphological analysis, collagen deposition, and activity of matrix metalloproteinase‐2 (MMP‐2). Methods Wistar rats were divided into groups: control; sham; only LLLT; only muscle injury and LLLT + injury. The rats were euthanized at 1, 3, and 7 days following cryoinjury to muscle that was removed for analysis. Results LLLT applied prior to muscle injury led to a reduction in myonecrosis and inflammatory cells, an increase of blood vessels and immature muscle fibers. An increase in MMP‐2 activity and a decrease in collagen deposition were also found, with a better collagen organization and distribution. Conclusion LLLT applied immediately prior to injury had positive effects during the muscle regeneration process. Therefore, this resource may have considerable therapeutic value, especially for athletes who practice sports in which there is a constant risk of muscle injury. Lasers Surg. Med. 47:571–578, 2015. © 2015 Wiley Periodicals, Inc.