Premium
Intraoperative, real‐time monitoring of blood flow dynamics associated with laser surgery of port wine stain birthmarks
Author(s) -
Yang Bruce,
Yang Owen,
Guzman John,
Nguyen Paul,
Crouzet Christian,
Osann Kathryn E.,
Kelly Kristen M.,
Nelson J. Stuart,
Choi Bernard
Publication year - 2015
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22369
Subject(s) - birthmark , port wine stain , medicine , surgery , blood flow , port wine , stain , pathology , laser , dermatology , radiology , staining , optics , physics
Background and Objective Port‐wine stain (PWS) birthmarks affect ∼22 million people worldwide. After several treatment sessions, complete disappearance of the PWS occurs in only ∼10% of treated patients. There is a need to develop a new strategy to improve the efficacy of each treatment session and the overall treatment outcome. The study objective was to determine how intraoperative measurements of blood flow correlate with treatment response assessed several weeks post treatment. Study Design/Materials and Methods We employed Laser Speckle Imaging (LSI) to measure intraoperative blood‐flow dynamics. We collected data from 24 subjects undergoing laser therapy for facial PWS birthmarks. Photographs were taken before treatment and at a follow‐up visit, and analyzed by two expert observers. Results Intraoperative LSI enables real‐time monitoring of blood‐flow dynamics in response to laser treatment and can inform clinicians on the need for focused re‐treatment. The degree of PWS blanching achieved is positively correlated with the log‐transformed acute blood‐flow reduction ( P = 0.022). Conclusion LSI is a simple, intraoperative monitoring tool during laser therapy of PWS birthmarks. LSI provides a single value for blood flow that correlates well with the degree of blanching achieved with laser therapy. Lasers Surg. Med. 47:469–475, 2015. © 2015 Wiley Periodicals, Inc.