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O perator Independent Focused High Frequency ISM Band for Fat Reduction: Porcine Model
Author(s) -
Weiss Robert,
Weiss Margaret,
Beasley Karen,
Vrba Jan,
Bernardy Jan
Publication year - 2013
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.22134
Subject(s) - subcutaneous fat , focused ultrasound , reduction (mathematics) , dermis , body contouring , high intensity focused ultrasound , ultrasound , medicine , nuclear medicine , treatment modality , abdominal fat , high energy , adipose tissue , urology , pathology , surgery , radiology , mathematics , obesity , geometry , engineering physics , weight loss , engineering
Background Selective fat reduction has been clearly shown for various methods and energy modalities including cryolipolysis and high intensity focused thermal ultrasound. Mathematical modeling of focused high frequency of the EM spectrum has indicated that selective heating of fat is possible using wavelengths not previous explored. The purpose of this study was to demonstrate in the porcine model that selective heating of fat is possible with a non‐contact, operator independent device. Methods High frequencies of the Industrial, Scientific and Medical (ISM) RF band were utilized to reduce abdominal fat in a porcine model. Practical application of mathematical modeling allowed an auto‐feedback loop to be developed to allow operator independent adjustment of energy to maintain subcutaneous fat at 45–46°C while overlying skin remained at 40–41°C. Results Treatments of three Vietnamese pigs were performed under anesthesia in a certified veterinary facility. Gross and microscopic histologic results demonstrated a marked reduction in adipocytes of the treated area after 4 treatments of a total of 30 minutes each, with incremental fat diminution after each treatment. A final 70% reduction of the abdominal fat layer was seen in the treated areas. Duplex ultrasound revealed a reduction of fat layer from 7.6 to 2.9 mm. Histologic evaluation revealed that epidermis, dermis, and adnexal structures such as hair follicles were unaffected by the treatment, while adipocytes were significantly affected. Conclusion A new model of fat reduction using high frequency RF has been successfully achieved in a porcine model. This has very positive implications in the development of an operator independent, contact free device for reduction of fat in clinical practice. Lasers Surg. Med. © 2013 Wiley Periodicals, Inc.