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Ultrasound‐guided photodynamic therapy for deep seated pathologies: prospective study
Author(s) -
Jerjes Waseem,
Upile Tahwinder,
Hamdoon Zaid,
Nhembe Farai,
Bhandari Rishi,
Mackay Sorcha,
Shah Priya,
Mosse Charles Alexander,
AS Brookes Jocelyn,
Morley Simon,
Hopper Colin
Publication year - 2009
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20853
Subject(s) - medicine , radiological weapon , prospective cohort study , swallowing , surgery , photodynamic therapy , ultrasound , radiology , chemistry , organic chemistry
Abstract Introduction Interstitial photodynamic therapy remains an attractive remedial option in minimally invasive surgery. Our aim in this prospective study was to evaluate the outcome following ultrasound‐guided iPDT of deep‐seated pathologies. Patients' reports on quality of life with clinical and radiological evaluation were the main end point parameters used to assess the outcome. Materials and Methods Sixty‐eight patients were referred to the UCLH Head and Neck Centre for treatment of various deep‐seated pathologies involving the head and neck region, upper and lower limbs. All patients underwent interstitial photodynamic therapy under general anaesthesia, using 0.15 mg/kg mTHPC as the photosensitising agent. Following treatment, patients were followed‐up for a mean of 7 months. Results All three patients who presented with visual problems reported improvement after treatment. Also, 14/17 patients reported improvement of breathing. Improvement of swallowing was reported by 25/30 patients; while speaking improvement was evident in 16/22 patients and 33/40 reported reduction in the disfigurement caused by their pathology. All five patients with impeded limb function reported some degree of improvement. Clinical assessment showed that half of the patients had ‘good response’ to the treatment and a third reported ‘moderate response’ with two patients being free of disease. Radiological assessment comparing imaging 6‐week post‐PDT to the baseline showed stable pathology with no change in size in 13 patients, minimal response in 18 patients, moderate response in 23 patients and significant response in 11 patients. Conclusion This study on 68 patients with deep‐seated pathologies undergoing interstitial photodynamic therapy provided evidence that PDT can be the fourth modality in the management of tissue disease. Lasers Surg. Med. 41:612–621, 2009. © 2009 Wiley‐Liss, Inc.