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Injectable treatments for adipose tissue: Terminology, mechanism, and tissue interaction
Author(s) -
Rotunda Adam M.
Publication year - 2009
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20807
Subject(s) - adipose tissue , medicine , adipocyte , clearance , mechanism (biology) , mechanism of action , surgery , pathology , urology , chemistry , philosophy , biochemistry , epistemology , in vitro
Background Just as injectable fillers have addressed the need for non‐surgical methods to restore desired volume, a number of injectable therapies purpor to play a comparable role to reduce undesired volume. Objective To review published literature on the history, mechanism of action, and tissue interaction of injectable methods that aim to reduce localized collections of fat. Results Mesotherapy is an injection technique that has medical and cosmetic applications and is often confused with injectable fat loss therapies; injection lipolysis describes non‐ablative fat reduction with agents (such as β‐agonists) that activate adipocyte lipolytic pathways; and adipolytic therapy using biologic detergents (such as deoxycholate) leads to permanent adipocyte ablation. None of these therapies have been cleared for use in fat reduction by any regulatory authority worldwide. Conclusions The mechanism of action and tissue effects of injectable fat reducing compounds are diverse but are becoming increasingly understood. Lasers Surg. Med. 41:714–720, 2009. © 2009 Wiley‐Liss, Inc.