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Dermal scatter reduction in human skin: A method using controlled application of glycerol
Author(s) -
Fox Matthew A.,
Diven Dayna G.,
Sra Karen,
Boretsky Adam,
Poonawalla Tasneem,
Readinger Allison,
Motamedi Massoud,
McNichols Roger J.
Publication year - 2009
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20767
Subject(s) - transdermal , optical coherence tomography , biomedical engineering , glycerol , stratum corneum , penetration (warfare) , human skin , in vivo , materials science , reduction (mathematics) , medicine , chemistry , pathology , ophthalmology , pharmacology , biology , mathematics , genetics , microbiology and biotechnology , geometry , organic chemistry , operations research
Background and Objective Previous studies in a hairless Guinea pig model showed that transdermal application of glycerol effected a temporary reduction in dermal scatter of light. This study focuses on the application of this protocol on human patients. Study Design/Materials and Methods After stratum corneal removal, glycerol was applied to human subjects using a low pressure transdermal application device. Optical coherence tomography imaging showed increased intensity of radiation reaching deeper regions in the skin and photographs showed enhanced visualization of dermal structures. Results/Conclusion Topically applied glycerol increased light penetration of in vivo corneal‐stripped skin. This minimally invasive approach to temporary dermal scatter reduction has the potential to improve the efficacy of light‐based diagnostic or therapeutic devices. Lasers Surg. Med. 41:251–255, 2009. © 2009 Wiley‐Liss, Inc.