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Photothermal response of superparamagnetic iron oxide nanoparticles
Author(s) -
Kim Jihoon,
Oh Junghwan,
Kang Hyun Wook,
Feldman Marc D.,
Milner Thomas E.
Publication year - 2008
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20650
Subject(s) - photothermal therapy , superparamagnetism , nanoparticle , irradiation , materials science , iron oxide nanoparticles , absorbance , absorption (acoustics) , iron oxide , chemistry , nuclear magnetic resonance , nanotechnology , magnetization , physics , chromatography , quantum mechanics , magnetic field , nuclear physics , metallurgy , composite material
Background and Objective Superparamagnetic iron oxide nanoparticles have been used as MRI contrast agents in medical imaging. The purpose of this study was to explore the photothermal response of superparamagnetic iron oxide nanoparticles for biomedical applications. Study Design/Materials and Methods Absorbance, temperature increase, and optical path length change of solutions of superparamagnetic iron oxide nanoparticles, SPIO and MION, in response to a 532 nm pulsed laser irradiation were measured. Results Both SPIO and MION showed absorption at 532 nm, temperature increase, and optical path length change. SPIO and MION underwent selective heating due to absorption of laser energy (532 nm). Conclusion Temperature increase and optical path length change of SPIO and MION in response to 532 nm pulsed laser irradiation demonstrate a potential application of these particles in biomedical imaging. For further study, additional experiments applying the photothermal response of SPIO and MION in tissues are required. Lesers Surg. Med. 40:415–421, 2008. © 2008 Wiley‐Liss, Inc.