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Using optical coherence tomography to evaluate skin sun damage and precancer
Author(s) -
Korde Vrushali R.,
Bonnema Garret T.,
Xu Wei,
Krishnamurthy Chetankumar,
RangerMoore James,
Saboda Kathylynn,
Slayton Lisa D.,
Salasche Stuart J.,
Warneke James A.,
Alberts David S.,
Barton Jennifer K.
Publication year - 2007
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20573
Subject(s) - optical coherence tomography , actinic keratosis , medicine , dermatology , sun exposure , biopsy , significant difference , nuclear medicine , pathology , ophthalmology , basal cell
Abstract Background and Objectives Optical coherence tomography (OCT) is a depth resolved imaging modality that may aid in identifying sun damaged skin and the precancerous condition actinic keratosis (AK). Study Design/Materials and Methods OCT images were acquired of 112 patients at 2 sun protected and 2 sun exposed sites, with a subsequent biopsy. Each site received a dermatological evaluation, a histological diagnosis, and a solar elastosis (SE) score. OCT images were examined visually and statistically analyzed. Results Characteristic OCT image features were identified of sun protected, undiseased, sun damaged, and AK skin. A statistically significant difference ( P <0.0001) between the average attenuation values of skin with minimal and severe solar elastosis was observed. Significant differences ( P <0.0001) were also found between undiseased skin and AK using a gradient analysis. Using image features, AK could be distinguished from undiseased skin with 86% sensitivity and 83% specificity. Conclusion OCT has the potential to guide biopsies and provide non‐invasive measures of skin sun damage and disease state, possibly increasing efficiency of chemopreventive agent trials. Lesers Surg. Med. 39:687–695, 2007. © 2007 Wiley‐Liss, Inc.