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Treatment of radiation‐induced dermatitis with light‐emitting diode (LED) photomodulation
Author(s) -
DeLand M. Maitland,
Weiss Robert A.,
McDaniel David H.,
Geronemus Roy G.
Publication year - 2007
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20455
Subject(s) - medicine , breast cancer , incidence (geometry) , skin reaction , dermatology , radiation therapy , skin cancer , surgery , cancer , nuclear medicine , physics , optics
Background and Objective Light‐emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation‐induced dermatitis in breast cancer. Materials and Methods Patients ( n = 19) were treated with LED photomodulation (Gentlewaves™, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity‐modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age‐matched controls ( n = 28) received IMRT without LED photomodulation. Results In LED‐treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED‐treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment. Conclusion LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy. Lasers Surg. Med. 39:164–168, 2007. © 2007 Wiley‐Liss, Inc.