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Ex vivo imaging of chronic total occlusions using forward‐looking optical coherence tomography
Author(s) -
Munce Nigel R.,
Yang Victor X.D.,
Standish Beau A.,
Qiang Beiping,
Butany Jagdish,
Courtney Brian K.,
Graham John J.,
Dick Alexander J.,
Strauss Bradley H.,
Wright Graham A.,
Vitkin I. Alex
Publication year - 2007
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20449
Subject(s) - medicine , optical coherence tomography , ex vivo , radiology , lumen (anatomy) , percutaneous , angioplasty , angiography , occlusion , conventional pci , peripheral , critical limb ischemia , biomedical engineering , in vivo , vascular disease , surgery , arterial disease , myocardial infarction , cardiology , biology , microbiology and biotechnology
Background and Objectives Percutaneous coronary interventions (PCI) of chronic total occlusions (CTOs) of arteries are more challenging lesions to treat with angioplasty and stenting than stenotic vessels due primarily to the difficulty in guiding the wire across the lesion. Angiography alone is unable to differentiate between the occluded lumen and the vessel wall and to characterize the content of the occlusion. New technologies to aid in interventional guidance are therefore highly desirable. We sought to evaluate tissue characterization in arterial (CTOs) by imaging ex vivo peripheral arterial samples with optical coherence tomography (OCT). Study Design/Materials and Methods Ex vivo arterialsamples were obtained from patients undergoing peripheral limb amputation. Samples were imaged in an enface orientation using an OCT system, enabling sequential acquisition of longitudinal images and volumetric reconstruction of cross‐sectional views of theoccluded arteries. Histology was performed for comparison. Results OCT imaging reliably differentiated between the occluded lumen and the underlying arterial wall in peripheral CTOs. OCT correctly identified tissue composition within the CTO, such as the presence of collagen and calcium and was also able to identify intraluminal microchannels. Conclusions OCT imaging of CTO anatomy and tissue characteristics may potentially lead to substantial improvements in PCI interventions by providing novel guiding capabilities. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.