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Incorporation of photodynamic therapy as an induction modality in non‐small cell lung cancer
Author(s) -
Ross Patrick,
Grecula John,
BekaiiSaab Tanios,
VillalonaCalero Miguel,
Otterson Gregory,
Magro Cynthia
Publication year - 2006
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20444
Subject(s) - photodynamic therapy , lung cancer , medicine , modality (human–computer interaction) , induction therapy , treatment modality , cancer , radiology , oncology , cancer research , chemistry , chemotherapy , computer science , organic chemistry , human–computer interaction
Background and Objectives Incorporation of photodynamic therapy (PDT) into the induction therapy regimen utilized for treatment of locally advanced primary non‐small cell bronchogenic carcinoma (NSCLC) is explored. Study Design/Materials and Methods We present a retrospective review of 41 patients diagnosed with non‐metastatic NSCLC who underwent induction PDT with chemotherapy and/or radiation. Results Fifty percent of patients initially deemed unresectable, were able to undergo definitive surgical resection after trimodality induction therapy. Twenty‐seven percent of patients considered to require pneumonectomy were able to have a lobectomy. The pathological stage was less than the preinduction clinical stage in 14 of 22 cases; of which four patients had no residual tumor. There was no 30/90‐day postoperative mortality. Mean survival was 35.9 months (lobectomy), 25.5 months (pneumonectomy) and 14.7 months (no surgery). Median survival was 78% (12 months) and 46% (36 months). The main postoperative complication following pneumonectomy was bronchopleural fistula formation. All patients who developed this complication had undergone trimodality induction therapy. Incorporation of PDT into the induction arsenal for patients with loco‐regionally advanced NSCLC may be safely performed. Conclusions PDT may define an alternative induction strategy for patients requiring pneumonectomy; further studies exploring the true efficacy of PDT as an induction modality are encouraged. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.