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Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor α‐mediated smooth airway muscle dysfunction
Author(s) -
Aimbire F.,
Bjordal J.M.,
Iversen V.V.,
Albertini R.,
Frigo L.,
Pacheco M.T.T.,
CastroFariaNeto H.C.,
Chavantes M.C.,
Labat R.M.,
LopesMartins R.A.B.
Publication year - 2006
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20357
Subject(s) - low level laser therapy , medicine , airway , laser therapy , radiation therapy , relaxation (psychology) , tumor necrosis factor alpha , necrosis , irradiation , laser , urology , anesthesia , endocrinology , physics , nuclear physics , optics
Background and Objective It is unknown if the decreased ability to relax airway smooth muscles in asthma and other inflammatory airways disorders can be influenced by low level laser therapy (LLLT) irradiation. To investigate if LLLT could reduce impairment in inflamed trachea smooth muscles (TSM) in rats. Study Design/Materials and Methods Controlled rat study where trachea was dissected and mounted in an organ bath apparatus with or without a TNF‐α solution. Results Low level laser therapy administered perpendicularly to a point in the middle of the dissected trachea with a wavelength of 655 nm and a dose of 2.6 J/cm 2 , partially restored TSM relaxation response to isoproterenol. Tension reduction was 47.0 % (±2.85) in the laser‐irradiated group compared to 22.0% (±2.21) in the control group ( P < 0.01). Accumulation of cAMP was almost normalized after LLLT at 22.3 pmol/mg (±2.1) compared to 17.6 pmol/mg (±2.1) in the non‐irradiated control group ( P < 0.01). Conclusion Low level laser therapy partially restores the normal relaxation response in inflamed TSM and normalizes accumulation of cAMP in the presence of isoproterenol. Lasers Surg. Med. 38:773–778, 2006. © 2006 Wiley‐Liss, Inc.