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Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital
Author(s) -
Kato H.,
Usuda J.,
Okunaka T.,
Furukawa K.,
Honda H.,
Sakaniwa N.,
Suga Y.,
Hirata T.,
Ohtani K.,
Inoue T.,
Maehara S.,
Kubota M.,
Yamada K.,
Tsuitsui H.
Publication year - 2006
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20346
Subject(s) - photodynamic therapy , medicine , stage (stratigraphy) , lung cancer , breast cancer , clinical trial , biopsy , lung , radiology , cancer , surgery , oncology , pathology , paleontology , chemistry , organic chemistry , biology
Background and Objectives We have been engaged in basic and clinical research on photodynamic therapy (PDT) and photodynamic diagnosis (PDD) for more than 25 years. Study Design/Materials and Methods PDT for 264 centrally located early‐stage lung cancer lesions yielded an initial complete response (CR) rate of 84.8%. PDT is now becoming a standard option for centrally located stage 0 (TisN0M0) and stage I (T1N0M0) lung cancer. It is an attractive option for elderly patients in poor physical condition. Results Recent results of interstitial PDT for peripheral‐type lung cancers suggest that it may be a promising local curative treatment modality for lesions less than 1.0 cm in diameter. Conclusions In this article, we introduce our recent clinical trials of PDT for lung cancers (both central and peripheral), and new techniques of PDD in sentinel node navigation biopsy for breast cancers. Moreover, we introduce basic research on cancers and infectious diseases in order to expand the clinical applications of PDT. Lasers Surg. Med. 38:371–375, 2006. © 2006 Wiley‐Liss, Inc.