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Targeted photodynamic therapy
Author(s) -
Solban Nicolas,
Rizvi Imran,
Hasan Tayyaba
Publication year - 2006
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20345
Subject(s) - photodynamic therapy , photosensitizer , medicine , treatment modality , cancer research , chemistry , pathology , surgery , photochemistry , organic chemistry
Background and Objectives Photodynamic therapy (PDT) is an emerging modality for the treatment of various neoplastic and non‐neoplastic pathologies. Study Design/Materials and Methods PDT usually occurs when reactive oxygen species (ROS) generated from light‐activated chemicals (photosensitizer, PS) destroy the target. For non‐dermatologic applications the PS are delivered systemically and accumulate, at different concentrations, in most organs. Results and Conclusion Typically there is a modest enhanced accumulation of the PS in tumor tissues, providing a first level of selectivity. Additional selectivity is provided by the confined illumination of the target area with the appropriate wavelength of light. For the treatment of pathologies in complex anatomical sites, such as in the peritoneal cavity, where restricted illumination is difficult; improved targeting of the PS is necessary to prevent damage to the surrounding healthy tissue. This article will focus on targeted PDT. Lasers Surg. Med. © 2006 Wiley‐Liss, Inc.