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Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features
Author(s) -
Kaviani Ahmad,
AtaieFashtami Leila,
Fateh Mohsen,
Sheikhbahaee Nasim,
Ghodsi Maryam,
Zand Nasrin,
Djavid Gholamreza Esmaeeli
Publication year - 2005
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20186
Subject(s) - photodynamic therapy , medicine , hematoporphyrin , basal cell carcinoma , photosensitizer , head and neck , carcinoma , basal cell , dermatology , pathology , surgery , chemistry , organic chemistry
Background and Objectives We aimed to treat different pathologic types of basal cell carcinomas (BCCs) using photodynamic therapy (PDT). Study Design/Materials and Methods Thirty lesions in six patients underwent PDT. The photosensitizer used was Photoheme, a hematoporphyrin derivative IX. It was injected intravenously at the dose of 2–3.25 mg/kg. After 24 hours, the lesions were illuminated by laser light (λ = 632 nm, light exposure dose = 100–200 J/cm 2 ). Lesions were evaluated pre and post‐operatively and at follow‐up sessions (of up to 6 months). Results After a single session of PDT, the average response rate in different histopathologic kinds of basal cell carcinoma (e.g., ulcerative, superficial, nodular, and pigmented forms) were 100%, 62%, 90%, and 14%, respectively. In patients who responded completely, the cosmetic results were excellent and there were no recurrence at 6th month of follow‐up. Conclusion Although PDT seems to be an effective treatment modality for superficial, ulcerative, and nodular BCCs, it is not recommended for pigmented lesions. Lasers Surg. Med. 36:377–382, 2005. © 2005 Wiley‐Liss, Inc.