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Lymph node metastasis in an animal model: Effect of piecemeal laser surgical resection
Author(s) -
Sapundzhiev Nikolay R.,
Dünne Anja A.,
Ramaswamy Annette,
Sitter Helmut,
Davis R. Kim,
Werner Jochen A.
Publication year - 2005
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20184
Subject(s) - medicine , lymph node , resection , surgery , lymph node metastasis , lymph , incidence (geometry) , metastasis , surgical margin , cancer , pathology , physics , optics
Background and Objectives Endoscopic laser surgical resection of advanced squamous cell carcinoma (SCC) often requires division of the tumor into several pieces. It is unknown if this approach influences the incidence of regional and distant metastases. Study Design/Materials and Methods In 143 rabbits VX2 SCC was induced. Eight days later the tumor was resected by two different methods. In the first group en bloc cold steel resection was performed. In the second group piecemeal laser resection was performed. On the 51th day the animals were sacrificed and examined for lymph node and distant metastases. Results After piecemeal laser resection 47.7% of the animals had lymph node metastases compared to 24.6% after en bloc resection ( P = 0.01). The incidence of distant metastases did not differ for the two groups. Conclusions In our model narrow margin piecemeal laser resection was associated with a higher incidence of metastases compared to wide en bloc surgical resection. The exact mechanism responsible for this increase is unclear. © 2005 Wiley‐Liss, Inc.