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Determination of chemical agent optical clearing potential using in vitro human skin
Author(s) -
Choi Bernard,
Tsu Laura,
Chen Eric,
Ishak Teresa S.,
Iskandar Sarah M.,
Chess Samuel,
Nelson J. Stuart
Publication year - 2005
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20116
Subject(s) - in vitro , refractive index , clearing , scattering , human skin , chemical agents , light scattering , chemistry , dynamic light scattering , materials science , biophysics , biomedical engineering , optics , nanotechnology , optoelectronics , medicine , biochemistry , biology , biochemical engineering , physics , finance , economics , genetics , engineering , nanoparticle
Background and Objectives: Optical clearing is a method that temporarily reduces the optical scattering of biological tissues. Study Design/Materials and Methods: To determine the optical clearing potential (OCP) of various chemical agents, we examined the change in reduced scattering coefficients of in vitro human skin after application directly to the dermal side. Results/Conclusions: We found that the mean agent OCP did not correlate with refractive index or osmolality. Lipophilic hyperosmotic agents had a mean OCP less than unity, indicating increased optical scattering. © 2005 Wiley‐Liss, Inc.