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He‐Ne laser effects on blood microcirculation during wound healing: A method of in vivo study through laser Doppler flowmetry
Author(s) -
Núñez Silvia Cristina,
Nogueira Gessé E.C.,
Ribeiro Martha S.,
Garcez Aguinaldo S.,
LageMarques José L.
Publication year - 2004
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20109
Subject(s) - laser doppler velocimetry , microcirculation , blood flow , wound healing , medicine , perfusion , in vivo , lesion , blood supply , biomedical engineering , pathology , surgery , biology , microbiology and biotechnology
Background and Objectives Low‐intensity laser therapy (LILT) is widely used for wound healing promotion and its mechanism of action may be due to an enhancement of blood supply. The aim of this study was to evaluate blood flow alterations in a wound healing model, using laser Doppler flowmetry (LDF) associated with a normalized perfusion parameter. Study Design/Materials and Methods An injury was provoked in 15 rats and blood flow was measured periodically over a period of 21 days. Control groups were established to evaluate LDF and He‐Ne laser effects on microcirculation. A 1 J/cm 2 dose was utilized, with 6 mW/cm 2 irradiance. Results The results demonstrated flow alterations provoked by lesion, and inflammatory response ( P < 0.05). There were no statistical differences between groups. Conclusions The results did not show a significant sustained effect on microcirculation with this He‐Ne dose. Lasers Surg. Med. 35:363–368, 2004. © 2004 Wiley‐Liss, Inc.