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60‐minute application of S‐Caine Peel prior to 1,064 nm long‐pulsed Nd:YAG laser treatment of leg veins
Author(s) -
Jih Ming H.,
Friedman Paul M.,
Sadick Neil,
Marquez Denise K.,
KimyaiAsadi Arash,
Goldberg Leonard H.
Publication year - 2004
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20044
Subject(s) - placebo , visual analogue scale , medicine , anesthesia , surgery , pain relief , topical anesthesia , laser , pathology , physics , alternative medicine , optics
Background and Objectives Advancements in laser treatment of leg veins necessitate concurrent investigations in topical anesthesia to minimize treatment‐related pain. To evaluate the efficacy of the S‐Caine Peel for providing topical anesthesia after a 60‐minute application. Study Design/Patients and Methods A randomized, double‐blinded, placebo‐controlled trial was performed in two centers. Sixty patients received S‐Caine Peel and placebo vehicle on different treatment sites for 60 minutes prior to laser treatment of leg veins using a 1,064 nm long‐pulsed Nd:YAG laser. Patients rated their level of pain using a visual analog scale. Adequacy of anesthesia and expressed pain at each site were rated by the investigator. Results The mean visual analog scale (VAS) was 27 mm for active sites compared to 43 mm for placebo ( P  < 0.001). Improved pain relief was noted for 67% of active versus 30% of placebo sites ( P  < 0.001). Anesthesia was judged adequate by the investigator for 55% of active compared with 12% of placebo sites ( P  < 0.001). Conclusions The S‐Caine Peel is safe and effective when applied for 60 minutes prior to laser therapy of leg veins. Lasers Surg. Med. 34:446–450, 2004. © 2004 Wiley‐Liss, Inc.

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