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Photodynamic effects of anthracyclin derivatives on squamous cell carcinoma cell lines of the head and neck
Author(s) -
Lippert B.M.,
Teymoortash A.,
Külkens C.,
Folz B.J.,
Werner J.A.
Publication year - 2004
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20040
Subject(s) - hematoporphyrin , photodynamic therapy , photosensitizer , epirubicin , medicine , head and neck , basal cell , carcinoma , cancer research , dermatology , chemistry , chemotherapy , pathology , photochemistry , surgery , organic chemistry , cyclophosphamide
Background and Objective In the last years, photodynamic therapy, performed with hematoporphyrin derivatives, gained in importance for the treatment of superficially situated malignomas. The use of hematoporphyrin as photosensitizer is limited especially by the low depth of penetration and its side effects. The aim of the present study was to evaluate the effectiveness of photodynamic therapy with anthracyclin derivates in squamous cell carcinoma cell lines. Study Design/Materials and Methods The photodynamic effects of the anthracyclin derivates adriamycin and epirubicin as well as the effects of the hematoporphyrin derivatives photofrin‐II and photosan‐3 were examined and compared in 10 squamous cell carcinoma cell lines derived from head and neck tumors. Results Beside their cytostatic effect, the applied cytostatics revealed a marked photodynamic effect. A statistically significant difference for photodynamic effects of both cytostatic agents and the hematoporphyrin derivates could not be shown. Conclusions These results revealed that the above mentioned cytostatics could be considered as possible alternative photosensitizer for photodynamic therapy. Lasers Surg. Med. 34:391–397, 2004. © 2004 Wiley‐Liss, Inc.