Premium
A first trial in the clinical application of photodynamic therapy for the prevention of restenosis after coronary‐stent placement
Author(s) -
Usui Mikio,
Miyagi Manabu,
Fukasawa Shinya,
Hara Takeshi,
Ueyama Naoya,
Nakajima Hitoshi,
Takata Ryu,
Sasame Atsuko,
Tamura Ken,
Naitou Yuuichi,
Yamashina Akira
Publication year - 2004
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.20018
Subject(s) - medicine , restenosis , stent , surgery , stenosis , radiology , coronary stent , photodynamic therapy , chemistry , organic chemistry
Abstract Background and Objectives The aim of this clinical study was to evaluate the safety of local delivery of a photosensitizer followed by photodynamic therapy (PDT), to determine its effectiveness in reducing in‐stent restenosis. Study Design/Patients and Methods Porfimer sodium was administered via a local delivery catheter to five coronary‐stent implanted lesions followed by irradiation with a pulse laser. Coronary angiography (CAG) was performed at the baseline, after the procedure and at a 6‐month follow‐up. Results By the 18‐month clinical follow‐up, no adverse events such as photodermatosis, or myocardial ischemia had occurred. At the follow‐up, no coronary embolization, dissection, or aneurysmal dilatation was observed in the CAG. In‐stent diameter stenosis, late loss, and loss index were 19.16±8.20%, 0.37±0.18 mm, and 0.19±0.12, respectively. No in‐stent restenosis was observed. Conclusions This study suggests that PDT, with local delivery of Porfimer sodium, is safe and may be a feasible technique in preventing in‐stent restenosis. Lasers Surg. Med. 34:235–241, 2004. © 2004 Wiley‐Liss, Inc.