Quantification of phthalocyanine concentration in rat tissue using laser–induced fluorescence spectroscopy | Zendy

Panjehpour Masoud | Zendy; Sneed Rick E. | Zendy; Frazier Donita L. | Zendy; Barnhill Mary Ann | Zendy; O'Brien Sherrie F. | Zendy; Harb William | Zendy; Overholt Bergein F. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Quantification of phthalocyanine concentration in rat tissue using laser–induced fluorescence spectroscopy

Author(s) -

Panjehpour Masoud,

Sneed Rick E.,

Frazier Donita L.,

Barnhill Mary Ann,

O'Brien Sherrie F.,

Harb William,

Overholt Bergein F.

Publication year - 1993

Publication title -

lasers in surgery and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 112

eISSN - 1096-9101

pISSN - 0196-8092

DOI - 10.1002/lsm.1900130107

Subject(s) - fluorescence , fluorescence spectroscopy , phthalocyanine , spectroscopy , chemistry , laser induced fluorescence , laser , materials science , analytical chemistry (journal) , nuclear magnetic resonance , biophysics , photochemistry , pathology , optics , medicine , biology , chromatography , nanotechnology , physics , quantum mechanics

Quantification of photosensitizer concentration in tissue should improve planning and outcome of photodynamic therapy. laser–induced fluorescence (LIF) can be used to measure in vivo fluorescence of photosensitizers in tissue. This study was designed to determine if in vivo fluorescence intensity of chloroaluminum phthalocyanine tetrasulfonate correlates with its concentration in different rat tissues. Following LIF measurements, the animals were humanely euthanized and the concentration of phthalocyanine in different tissues was determined using chemical extraction technique. The correlation of phthalocyanine fluorescence intensity and its concentration was determined for each tissue using Pearson product‐moment correlation analysis. A strong correlation between in vivo phthalocyanine fluorescence intensity and its concentration was found for spleen, kidney, liver, and chemically induced mammary adenocarcinoma. Low correlation was found for thigh skin and planum of nose. No correlation was found for thigh muscle and tongue. © 1993 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research