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Reduced tumor cell transfer with contact neodymlum‐yttrium‐aluminium
Author(s) -
Maker Vijay K.,
Elseth Kim M.,
Radosevich James A.
Publication year - 1992
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900120310
Subject(s) - laser , surgery , pathology , medicine , biomedical engineering , optics , physics
The local recurrence of tumor growth after surgery is thought, in part, to be a consequence of seeding of tumor cells from the primary lesion. This study was directed at determining if the contact Nd:YAG laser provides any advantage over the use of traditional scalpel disection for tumor resection. Five human tumor tissue culture cell lines were studied in this report. They included MCF‐7 (breast), HeLa (cervical), SW‐780 (bladder), HT29 (colon), and A549 (lung). Using a scalpel blade or contact laser scalpel (with or without laser energy), the ability to transfer viable cells from dense cell stocks to new tissue culture wells was tested. Using the A549 cell line, the extent that these instruments were able to “seed” tumor cells was also assessed in a soft agar, in vitro, “incision” model. Results from these studies suggest that the contact laser scalpel has a significantly lower potential to transmit tumor cells, when compared to traditional scalpel blades. © 1992 Wiley‐Liss, Inc.