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Relation between polyporphyrin distribution and blood brain barrier changes in the rat glioma model
Author(s) -
Ji Ying,
Walstad Diana L.,
Brown J. Tony,
Powers Stephen K.
Publication year - 1992
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900120210
Subject(s) - evans blue , blood–brain barrier , glioma , distribution (mathematics) , permeability (electromagnetism) , brain tissue , brain tumor , pathology , chemistry , central nervous system , biology , medicine , cancer research , biochemistry , mathematical analysis , mathematics , membrane
Photofrin™ (a polyporphyrin mixture) distribution in a rat glioma model was studied in relation to changes in the blood brain barrier (BBB). At selected intervals after intraperitoneal injection of Photofrin™, the concentration of polyporphyrins (PP) and Evans Blue Dye, an indicator of BBB permeability, were determined for tumor, brain adjacent to tumor (BAT), and normal brain tissue. Contrary to earlier reports of maximal accumulation at 4–24 hours, tumor levels of PP increased throughout the 96 hour measurement period. During the early stages of tumor development, PP uptake by tumor appeared to be less correlated to BBB disruption. We conclude that passive diffusion through an incompetent BBB does not completely explain PP accumulation in tumor tissue. © 1992 Wiley‐Liss, Inc.