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Histologic evaluation of rat mammary tumor necrosis by interstitial Nd:YAG laser hyperthermia
Author(s) -
Dowlatshahi Kambiz,
Babich Debra,
Bangert Julee D.,
Kluiber Rudolph
Publication year - 1992
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900120208
Subject(s) - coagulative necrosis , hyperthermia , laser , necrosis , irradiation , materials science , nuclear medicine , biomedical engineering , chemistry , pathology , medicine , optics , physics , nuclear physics
The extent of coagulative necrosis caused by interstitial laser hyperthermia was measured for different quantities of laser energy in a rat mammary tumor model. Continuous wave Nd:YAG laser at a power level of 5 W was focused onto a 600 JA diameter bare tip quartz fiber and placed inside a 19‐gauge needle, which allowed the para‐axial flow of normal saline at 1 cc/min. A microthermocouple soldered to the outside of the probe continuously provided the interstitial temperature. After the probe was inserted into the tumor, it was withdrawn as laser energy was administered at a rate sufficient to maintain the temperature within 42–45°C. Tumors were excised after 48 hours, fixed in formalin, cut in 3 mm slices, and the coagulated surfaces measured microscopically. Laser fiber transmission loss was 1% per 1,000 J of laser energy and the average time required to coagulate 1 cc of tumor was 2 minutes. There was a statistically significant correlation between the volume of tumor necrosis and the level of laser irradiation (r = 0.71, P <0.001). It is concluded that the described technique is an efficient method of tumor coagulation by interstitial laser hyperthermia and proportionally larger volumes of necrosis are created with greater amounts of laser energy. © 1992 Wiley‐Liss, Inc.