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Effect of steroids or tissue preceding on edema and tissue thermal coagulation after CO 2 laser impact
Author(s) -
Sheppard LisaMarie,
Werkhaven Jay,
Mickelson Samuel,
Crissman John D.,
Peterson Edward,
Jacobsen Gordon
Publication year - 1992
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900120205
Subject(s) - carbon dioxide laser , edema , extravasation , medicine , coagulation , laser coagulation , basal (medicine) , laser , surgery , anesthesia , pathology , chemistry , nuclear medicine , laser surgery , physics , visual acuity , optics , insulin
The carbon dioxide laser is frequently used in laryngeal microsurgery. Some surgeons have empirically used preoperative steroids or precooling with ice prior to laser impact to limit the resultant tissue thermal coagulation and/or edema. An animal model was designed to quantitatively test these effects. Depillated areas of rat skin were exposed to a CO 2 beam of 1 mm diameter at 15 W for 0.1 sec after either administration of Decadron (0.25 mg/kg) immediately prior to impact or precooling more than 10 o C below basal body temperature. Measurement of edema was quantitated as extravasation of Evan's blue dye that had been injected intravenously. Tissue thermal coagulation was measured on hematoxylin and eosin stained histologic sections. In comparison to controls, statistically significant reduction in edema was seen only at the 24 hour time period after laser exposure for the steroid group ( P <.002) but not for the precooling group. Tissue thermal coagulation was significantly smaller for both the steroid and the ice group ( P < .006 and P < .001, respectively) when compared to controls. © 1992 Wiley‐Liss, Inc.