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Photodynamic therapy in gastrointestinal cancer
Author(s) -
Karanov Strashimir,
Shopova Maria,
Getov Hristo
Publication year - 1991
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900110502
Subject(s) - photodynamic therapy , medicine , gastrointestinal cancer , cancer , cancer therapy , dermatology , colorectal cancer , chemistry , organic chemistry
Six patients with an early stage of gastrointestinal (GI) cancer (T 1 N o M o , stage I) were successfully treated by photodynamic therapy (PDT) as follows: esophagus‐1, stomach‐2, rectum‐3. The patients were photosensitized 72 hrs prior to treatment with pure hematoporphyrin at a dose of 5.10 −6 kg/kg b.w. in a slow intravenous infusion. Argon‐pumped dye laser light at 0.630 μm wave‐length was used in single and multiple treatment sessions with the power density ranging from 0.015 to 0.192 W.m −2 and a dose varying from 0.320 to 1.600 kJ.m −2 . Tumor eradication (complete response) was obtained in each of the patients. No early or late treatment related complications were recorded. The patients were followed‐up in the course of 7–16 months after treatment and no local recurrence or general development of disease (metastases) were reported. PDT in the early stage of GI carcinoma was recognized as a radical therapeutic method in clinical oncology.