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Direct CO 2 laser “revascularization” of the myocardium
Author(s) -
Landreneau Rodney,
Nawarawong Weerachai,
Laughlin Harold,
Ripperger Joseph,
Brown Olen,
McDaniel Wayne,
McKown Daniel,
Curtis Jack
Publication year - 1991
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900110109
Subject(s) - medicine , cardiology , blood flow , sonomicrometry , perfusion , revascularization , circumflex , cardiopulmonary bypass , artery , occlusion , hemodynamics , myocardial infarction
Abstract Evidence of regional myocardial perfusion and contractile function after direct CO 2 laser myocardial revascularization (DLR) is lacking. We examined myocardial segment shortening, adenine nucleotide concentrations, and regional blood flow after DLR of the left anterior descending coronary artery (LAD) distribution before and after its proximal ligation in seven anesthetized conditioned dogs. Sonomicrometry assessed myocardial fiber shortening and radioactive microspheres were used to estimate baseline regional blood flows. Cardiopulmonary bypass was followed by cardioplegia arrest. Laser channels (1 mm diameter) were made every 3 to 5 mm in the LAD region with an 80 watt Lasersonics CO 2 unit. Bypass was terminated, the LAD occluded, and parameters reassessed. Core samples of myocardium from the lased LAD and control circumflex area were taken to assess adenine nucleotides. After occlusion, LAD distribution blood flow and myocardial shortening were reduced to pre‐lasing ischemic controls. Adenine nucleotides were reduced in the LAD region relative to the control CMX area. DLR cannot be relied upon to acutely revascularize the ischemic myocardium.