Premium
Effect of blood upon the selective ablation of atherosclerotic plaque witha pulsed dye laser
Author(s) -
Gregory Kenton W.,
Prince Martin R.,
Lamuraglia Gleen M.,
Flotte Thomas J.,
Buckley Lisa,
Tobin Jill M.,
Ziskind Andrew A.,
Caplin John,
Anderson R. Rox
Publication year - 1990
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900100605
Subject(s) - ablation , saline , irradiation , perfusion , absorption (acoustics) , laser , aorta , medicine , materials science , optics , physics , nuclear physics , composite material
Laser angioplasty systems with laser energy preferentially absorbed by atherosclerotic plaque may offer a safe method of plaque removal. This study evaluated the effect of blood upon selective energy absorption using a pulsed dye lasser at 480 nm. Intra‐arterial laser irradiation of normal rabbit femoral arteries demonstrated a perforation threshold energy with blood perfusion of 13.1 mJ per pulse compared to 87.9 mJ with saline ( P < .0001), indicating a deleterious effect in the presence of blood. An adverse effect upon arterial healingt at 3 days was noted in sheep following intra‐arterial irradiation during blood but not saline nerfusion. Normal and atherosclerotic human aorta ablation thresholds differed significantly ( P < .0002) under saline (plaque: 20 mJ and normal: 20 mJ) was not significant. We conclude that absorption of laser energy by blood can reduce the effect of differential absorption by endogenous chromophores in normal and pathologic vascular tissues and, therefore, removal of blood may be a prerequisite for selective ablation of atherosclerotic plaques.