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Dihematoporphyrin Ether‐Induced photosensitivity in laryngeal papilloma patients
Author(s) -
Mullooly Virginia M.,
Abramson Allan L.,
Shikowitz Mark J.
Publication year - 1990
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900100408
Subject(s) - medicine , erythema , photosensitivity , dermatology , papilloma , hyperpigmentation , papillomatosis , edema , phototoxicity , surgery , irritation , pathology , physics , quantum mechanics , immunology , biochemistry , chemistry , in vitro
Twenty‐six patients with recurrent laryngeal papillomatosis received 2.5 mg/kg of Dihematoporphyrin Ether (DHE) intravenously prior to photodynamic therapy. All patients experienced some degree of photosensitivity, the only known side effect of DHE. Reported reactions included mild erythema and inflammation (88%), swelling (58%), blistering (23%), ocular discomfort (61.5%), pruritus (38%), and skin hyperpigmentation (46%). Length of sensitivity ranged from 4–17 weeks, with an average duration of 9 weeks. No long‐term debilitating sequelae were noted. Degree of skin reaction mainly depended on how compliant the patient was in following precaution instructions. Although restrictive precautions were often difficult to strictly adhere to, most patients felt the potential benefits of the therapy far out‐weighed any inconvenience.