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Ablation of endometriotic implants in rabbits by hematoporphyrin derivative photoradiation therapy using the gold vapor laser
Author(s) -
Petrucco Oswald M.,
Sathananden Muttukrishna,
Petrucco Michael F.,
Knowles Simon,
McKenzie Lorraine,
Forbes Ian J.,
Cowled Prudence A.,
Keye William E.
Publication year - 1990
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900100407
Subject(s) - hematoporphyrin , endometriosis , photodynamic therapy , irradiation , medicine , necrosis , pathology , chemistry , nuclear medicine , physics , organic chemistry , nuclear physics
In a rabbit model, endometriotic lesions were utilized to study hematoporphyrin derivative (HPD) uptake and the effect of photoradiation using the gold vapor laser. Morphological studies confirmed successful induction of ectopic endometrial growth and the lesions displayed preferential HPD uptake compared to normal intraperitoneal structures. Gold vapor laser irradiation of the lesions in HPD pretreated animals produced necrosis of the endometriotic lesions leaving surrounding tissues healthy. Results from this study suggest that HPD‐mediated photodynamic therapy may be a suitable means of treating endometriosis in the human.