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Nd:YAG laser‐induced hyperthermia in a mouse tumor model
Author(s) -
Waldow Stephen M.,
Morrison Paul R.,
Grossweiner Leonard I.
Publication year - 1988
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900080510
Subject(s) - hyperthermia , mammary carcinoma , laser , nuclear medicine , complete response , materials science , medicine , biomedical engineering , carcinoma , pathology , surgery , optics , chemotherapy , physics
Hyperthermic tumor response induced by 1,064‐nm radiation from an Nd:YAG laser was investigated in DBA/2J female mice bearing the SMT‐F mammary carcinoma. The measured temperature‐depth profiles indicate that hyperthermic temperatures can be achieved in tumors ranging from 3 to 8 mm thick at power inputs on the order of 1 W. For small tumors, a 5‐week complete response rate exceeding 50% required 45 minutes at 45.0°C. Control of large tumors (6–8 mm thick) was not achieved. The observed tumor response rates are consistent with semiempirical time‐temperature relations based on other heating modalities.