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Pathology of laser‐induced experimental aneurysms
Author(s) -
Ammirati Mario,
Ostertag Helmut,
Rabin Eleanor,
Ciric Ivan
Publication year - 1988
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900080314
Subject(s) - adventitia , lumen (anatomy) , aneurysm , medicine , carotid arteries , pathology , pathological , radiology , surgery
Abstract Aneurysms were produced in the common carotid artery of 35 rats by milliwatt CO 2 laser welding of an adventitia patch over a hole. The aneurysmal sac was formed by collagen; the lumen was covered by an endothelial‐like lining and partially thrombosed. The pathology of these aneurysms is similar to spontaneously occurring intracranial human aneurysms. This aneurysm model has properties (reliability, spontaneous bleeding tendency, minimal vessel manipulation, and pathological features) that make it theoretically advantageous for the induction of experimental intracranial aneurysms in larger animals.