Premium
Characteristic autofluorescence for cancer diagnosis and its origin
Author(s) -
Yuanlong Yang,
Yanming Ye,
Fuming Li,
Yufen Li,
Paozhong Ma
Publication year - 1987
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900070617
Subject(s) - autofluorescence , porphyrin , cancer , nuclear magnetic resonance , fluorescence , pathology , chemistry , materials science , medicine , optics , photochemistry , physics
The autofluorescence spectra of human tissues excited with the 365‐nm line of pulsed xenon ion laser have been measured. The autofluorescence spectra of cancer tissues usually show characteristic peaks near 630 nm and 690 nm, which do not appear in the spectra of the corresponding normal tissues. This characteristic fluorescence can be taken as a criterion for cancer diagnosis; a consistency of 89% with the traditional biopsy method has been obtained in preliminary clinical application to the diagnosis of buccal carcinoma. Spectroscopic investigations suggest that the porphyrin compounds localized and retained in cancer tissues might be responsible for this characteristic autofluorescence.