Premium
Endogenous porphyrin fluorescence in tumors
Author(s) -
Harris David M.,
Werkhaven Jay
Publication year - 1987
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900070605
Subject(s) - porphyrin , fluorescence , chemistry , endogeny , pathology , medicine , biochemistry , optics , physics
Abstract The fluorescence of endogenous porphyrins in tumors has been attributed to the presence of several different species of bacteria inhabiting ulcerated and necrotic tissues. We have examined this “autofluorescence” in carcinogen‐induced tumors in the hamster oral mucosa and in patients with cancer of the oral cavity. In several instances, bright autofluorescence of normal tissues has been observed. This represents a potential false‐positive identification of cancer when systemic hematoporphyrin derivative fluorescence is used as a diagnostic technique.