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Optical dosimetry in photodynamic therapy
Author(s) -
Grossweiner Leonard I.
Publication year - 1986
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900060508
Subject(s) - photodynamic therapy , photosensitizer , hematoporphyrin , dosimetry , photobleaching , optics , irradiance , radiant energy , penetration depth , materials science , nuclear medicine , chemistry , optoelectronics , radiation , medicine , fluorescence , physics , photochemistry , organic chemistry
Abstract The diffusion approximation for the radiant flux distribution in a tissue layer has been applied to optical dosimetry in photodynamic therapy of malignant tumors. The model assumes that tumor eradication requires a minimum absorbed energy by the localized photosensitizer, taken as 0.19 J/cm 3 for hematoporphyrin derivative (HPD) at 630 run. The analysis leads to the required incident irradiance for front surface illumination as a function of the tumor depth, the optical penetration depth of the tumor, and the concentration of localized sensitizer. The effect of HPD photobleaching on the required light dose and drug dose levels is considered. The results are given in tabular form for typical clinical applications.