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Reduction of local tumor recurrence by excision with the CO 2 laser
Author(s) -
Lanzafame Raymond J.,
Rogers David W.,
Nairn John O.,
Defranco Cecilia A.,
Ochej Helen,
Raymond Hinshaw J.
Publication year - 1986
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900060503
Subject(s) - medicine , surgery , laser , resection , mammary carcinoma , laser surgery , carcinoma , physics , optics
This study was undertaken to determine the effect of CO 2 laser surgery on the incidence of local recurrence following tumor resection. Thirty female Fisher 344 rats were implanted with R3230AC mammary carcinoma. All tumors were completely excised 18–21 days post‐implantation. In 15 animals, the resection was done with a scalpel. Fifteen animals underwent laser excision with the Sharplan 733 CO 2 laser (TEMoo, 125mm handpiece, 25W continuous wave). Primary tumor size was 17.6 ± 1.4mm in the scalpel group and 21.2 ± 6.3mm in the laser group. Tumor recurred in 14/15 (93.4%) of the scalpel group and 5/ 15 (33.3%) of the laser group (p<0.001). The site of recurrence was incisional in 13/15 (86.7%) of the scalpel group and 3/15 (20%) of the laser group (p<0.001). Axillary metastases occurred in 2/15 (13.3%) in each group. The disease‐free interval was 26 days in the laser group and 12 days in the scalpel group. The CO 2 laser is an effective surgical adjunct to reduce local tumor seeding and recurrence.