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Laser treatment of keloids: A clinical trial and an in vitro study with Nd:YAG laser
Author(s) -
Abergel R. Patrick,
Dwyer Richard M.,
Meeker Cheryl A.,
Uitto Jouni,
Lask Gary,
Kelly A. Paul
Publication year - 1984
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900040310
Subject(s) - laser , medicine , dermatology , laser treatment , clinical trial , surgery , pathology , optics , physics
Biochemical studies utilizing keloid fibroblast cultures revealed that Nd: YAG laser selectively suppressed collagen production by these cells. Based on these in vitro observations, eight patients with keloids were treated with Nd:YAG laser in a nondestructive manner. Results, with a 3‐year follow‐up, indicated flattening and softening of the lesions. Thus, the results suggest that Nd:YAG laser is an effective treatment modality for keloids, and its mechanism may involve bioinhibition of fibroblast functions.