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Laser photoradiation therapy of cancer: Possible role of hyperthermia
Author(s) -
Berns Michael W.,
Coffey Joan,
Wile Alan G.
Publication year - 1984
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900040112
Subject(s) - hematoporphyrin , hyperthermia , laser , cancer therapy , nuclear medicine , chemistry , laser therapy , cancer , medicine , materials science , photodynamic therapy , optics , physics , organic chemistry
Two patients were treated at 20 different tumor sites by hematoporphyrin derivative (HPD) photoradiation therapy (PRT). An infrared detector was used to record changes in surface temperature during laser exposure. A temperature rise of up to 4.9 °C was recorded for a total energy of 15–30 J/cm 2 and less than 150 mW/cm 2 . For 508 mW/cm 2 and 15–20 J/cm 2 a temperature rise of 7.0 °C was detected. The results suggest a possible role of hyperthermia in HPD‐PRT.