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Evaluation of hematoporphyrin photoradiation therapy to treat choroidal melanomas
Author(s) -
Bruce Robert A.
Publication year - 1984
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900040108
Subject(s) - hematoporphyrin , photodynamic therapy , medicine , choroidal melanoma , melanoma , nuclear medicine , chemistry , cancer research , organic chemistry
Hematoporphyrin derivative‐photoradiation therapy (HPD‐PRT) was used to treat choroidal melanomas in 23 human subjects. Tumor sizes were divided into three categories: less than 500 mm 3 (11 patients), 500‐1,000 mm 3 (four patients), and greater than 1,000 mm 3 (eight patients). Tumors were exposed to 630 nm laser light at total doses of 300‐3,000 J/cm 2 . Significant tumor reduction was noted in the subjects with initial tumor volume of less than 500 mm 3 and 500‐1,000 mm 3 .