Premium
Clinical measurement of tumor fluorescence using a new diagnostic system with hematoporphyrin derivative, laser photoradiation, and a spectroscope
Author(s) -
Kato Harubumi,
Ono Jutaro,
Konaka Chimori,
Kawate Norihiko,
Yoneyama Kazuo,
Kinoshita Komei,
Nishimiya Katsuaki,
Sakai Harumasa,
Noguchi Masayuki,
Tomono Takahisa,
Hayata Yoshihiro,
Aizawa Katsuo,
Kawasaki Satoru,
Tokuda Yasuaki
Publication year - 1984
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900040107
Subject(s) - hematoporphyrin , fluorescence , derivative (finance) , spectrometer , optics , laser , materials science , chemistry , nuclear medicine , biomedical engineering , medical physics , medicine , photodynamic therapy , physics , organic chemistry , financial economics , economics
Hematoporphyrin derivative (HPD) is retained by malignant tumors and emits fluorescence with peaks of 630 and 690 nm wavelength when HPD is exposed to light. It is therefore theoretically possible to make a diagnosis of malignant tumors by detecting the fluorescence of HPD. The authors developed a spectroscope system compatible with fiberoptic endoscopes to analyze the shape of the fluorescence light spectrum. We could clearly recognize the HPD‐specific fluorescence in human cancer foci. This system can be applied to the measurement of the relative amount of HPD absorbed in superficial tumor tissue before the photodynamic therapy. This might suggest the extent of tumor. The clinical diagnostic applications of this system are described in this study.