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Laser oncology in Italy: experimental research and clinical applications at the National Cancer Institute, Milan
Author(s) -
Emanuelli H.,
Bandieramonte G.,
Marchesini R.,
Fava G.,
Rodari A.,
Colombo M. P.,
Costa A.,
Spinelli P.,
Zunino F.,
Chiesa F.,
Cascinelli N.,
Andreola S.,
Pariente R.,
Canti G. F.
Publication year - 1983
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900020409
Subject(s) - medicine , laser surgery , otorhinolaryngology , laser , cancer , medical physics , surgery , optics , physics
CO 2 , Nd:YAG, and argon lasers have been used for 5 years for experimental and clinical procedures at the National Cancer Institute of Milan under the auspices of the National Research Council. Experimental data regarding tumor cell spread through lymphatic and hematic channels and cell viability in the fumes after CO 2 laser irradiation are reported. New advantages in the combined treatment modalities have been demonstrated, since the synergism between the low power argon laser beam and chemotherapeutic agents (anthracyclines) was assessed on cell cultures and the least toxic and the most effective doses of the drugs were identified. Due to the optical properties of the laser beam, physical measurements of the delivered energy and mathematical calculation of the energy per tissue volume unit to be ablated increase the precision in microsurgery especially when conservative managements are indicated. Main applications in surgical oncology, and comparison versus conventional methods, both with vaporization and excisional techniques, according to specific therapeutic protocols, in general surgery, otolaryngology, gynecology, and endoscopy, even on an outpatient basis, are finally illustrated in a series of 600 cases.